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ea0037ep54 | Adrenal cortex | ECE2015

A phase 1, randomised, open-label, four-period crossover, single-dose study to evaluate the pharmacokinetics of hydrocortisone modified release tablets

Johannsson Gudmundur , Lennernas Hans , Marelli Claudio , Rockich Kevin , Skrtic Stanko

Novel biopharmaceutical techniques have allowed the development of a hydrocortisone modified release (MR) tablet (once-daily administration for replacement therapy in adrenal insufficiency) mimicking more closely the physiological serum cortisol profile. Robust bioavailability is needed to secure this new treatment safety.Aims: To compare single-dose pharmacokinetics (PK) of MR tablets manufactured at two different sites by assessing intra-subject variab...

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ea0044ja5 | Society for Endocrinology Journal Award–Clinical Endocrinology | SFEBES2016

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Johannsson Gudmundur , Falorni Alberto , Skrtic Stanko , Lennernas Hans , Quinkler Marcus , Monson John P , Stewart Paul M

Volume 82, Issue 1, January 2015, Pages 211. DOI: 10.1111/cen.12603...

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ea0032p24 | Adrenal cortex | ECE2013

Management of Addison's disease patients using dual release hydrocortisone during periods of intercurrent illness

Simonsson Ulrika SH , Skrtic Stanko , Lennernas Hans , Marelli Claudio , Johannsson Gudmundur

Introduction: Current management of intercurrent illness (ICI) in adrenal insufficiency (AI) is inadequate. We attempted to optimise ICI regimens with pharmacokinetic simulations of a dual-release (DR) hydrocortisone (HC) and tested them in a formal clinical trial.Methods: This work consisted of: i) dosing recommendations in episodes of mild ICI with DR-HC using simulations with a population pharmacokinetic model, ii) collection of ICI episodes with incr...

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Endocrine Abstracts

A phase 1, randomised, open-label, four-period crossover, single-dose study to evaluate the pharmacokinetics of hydrocortisone modified release tablets

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Management of Addison's disease patients using dual release hydrocortisone during periods of intercurrent illness

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